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KMID : 1161920180150020042
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Journal of Medicine and Life Science
2018 Volume.15 No. 2 p.42 ~ p.45
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Understanding animal models on colorectal cancer
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Lim Do-Young
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Abstract
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Colorectal cancer (CRC) is a third leading cause of cancer-related death in cancer patients. Sporadic and inflammation-related colon carcinogenesis are major mechanism of colorectal cancer. In vivo CRC models have been developed and implicated to understand their mechanisms upon a different type of CRC. Moreover, recently animal models have played important roles in chemopreventive and preclinical trials over the years. In this mini-review, the aim is to introduce various animal models of CRC and help the understanding to establish in vivo experimental plans according to the cancer type of CRC.
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KEYWORD
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Colorectal cancer, Animal model, Sporadic colorectal cancer, Inflammatory colorectal cancer
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